BIOPHYSICS - analytical program

Structuring by years of study:

- the analytical programme is intended for students of the first year (one semester), specialising in general medicine

Lecture: 28 hours

1. Subject and importance of biophysics (1 hour)

2. Elements of atom and molecule physics, structure, interactions and molecular bonding, applications in biophysics (3 hours)

3. Notions of thermodynamics of living systems (principles, thermodynamic functions, thermodynamics of biological processes, metabolism, applications) (3 hours)

4. Disperse systems (water, solutions: molecular structure, physical properties, applications) (2 hours)

5. Biomechanics (forces, fluid mechanics, hemodynamics, acoustics, mechanical waves, applications in medicine and biophysics) (3 hours)

6. Cell membrane (organization and functions, composition, membrane patterns, intercellular communication mechanisms and systems, membrane transport phenomena) (4 hours)

7. Biophysics of complex systems: receptors and analysers (visual analyser, auditory analyser) (3 hours)

8. Bioelectricity and biomagnetism, therapeutic applications; properties of impulse transmission in nerve and muscle cells (3 hours)

9. Lasers and applications in medicine (1 hour)

10. Ionizing and non-ionizing radiation: characteristics, interaction with living tissue, radiation protection, medical applications) (2 hours)

11. Physical principles of medical imaging: (radiography, ultrasound, CT, MRI, scintigraphy, PET) (3 hours)

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Practical work (LP/PW): 28 hours

1. Notions of work safety in the laboratory, physical quantities, units of measurement

2. Measurements, experimental errors, statistical interpretation of experimental data

3. Thermodynamic measurements (specific heat, latent heat, heat capacity)

4. Determination of the surface tension coefficient of a surfactant solution

5. Viscometry (principles, methods, determinations)

6. Measuring the refractive index of liquids with the refractometer

7. Determination of the concentration of an optically active solution using the polarimeter

8. Optical microscopy; characteristics of laser radiation

9. Spectral analysis (principles, types, medical applications)

10. Bioelectrical measurements (potentials, electrolysis, EKG principles)

11. Study of ultrasound (propagation, reflection, determination of the attenuation coefficient)

Bibliography :

1. Russell K. Hobbie, Bradley J. Roth, Intermediate Physics for Medicine and Biology,

Springer, 2007

2. Irving P. Herman, Physics of the human body, Springer, 2007

3. R. Glaser, Biophysics, Springer Verlag Berlin 1999

4. S. Buzatu, Biofizică medicală, Editura Sitech, 2003

5. J. Neamţu, P.G. Anoaica, Fizică – Lucrări practice de laborator, Editura Medicală

Universitară Craiova 2003

Disciplines the analytical programme relates to:

• cell biology, biochemistry, physiology, medical imaging

Basic content:

• general notions about the physical processes involved in the functioning of the living organism
• principles of physical methods used in the study of biosystems
• impact of physical factors on the functioning of biosystems
• physical principles used by medical devices

Specific objectives:

• acquiring of general notions related to physical processes and phenomena (mechanical, thermal, electrical, radiative) occurring in biological systems, with a special emphasis on the human body
• acquiring basic knowledge of the medical equipment used by the staff specialised in investigations and analyses in health units
• the ability to integrate acquired knowledge with that of other disciplines