NCmicroAD

Etape

 

Step 1 ( 3 months )

Obiective

Objective 1.1: This phase will be primarily aim at acquiring and breeding of transgenic animals that will be used in the present project.
Objective 1.2: Within this stage the toxicity of Na channel blockers will be tested on existing non-transgenic animal in the animal facility of the University of Medicine and Pharmacy of Craiova.

Activitati

Activity 1.1.1 - Acquisition of transgenic animals
Activity 1.2.1 - Establishing protocols and drafting a database

Step 2 ( 9 months )

Obiective

2P-LSM studies on young animals that received sodium channel blocker will be performed. This will help understand how Na blockers will influence microglia dysfunction in incipienteale stages of AD.

Activitati

Activity 2.1.1 - 2P-LSM images will be acquired that will be corelated with young animals excitability
Activity 2.1.2 - 2P-LSM images will be acquired that will be corelated with old animals excitability

Step 3 ( 9 months )

Obiective

Finalize research, publish and promote the results

Activitati