The fundamental basis of this study is the fact that GPER (GPR30) acts as a fast-acting estrogen receptor that can be stimulated, or blocked by pharmacological agents or other means. The role of GPER in physiology, pharmacology and pathology is poorly understood, and is significantly different from the classical nuclear hormone estrogen receptors, ER? and ER?, respectively.
All experiments will be performed by Assoc Prof. Dr. Andrei Adrian Tica and Assist. Prof. Oana Sorina Tica, in the laboratory of the Pharmacology Department, Faculty of Medicine, University of Medicine and Pharmacy Craiova – Romania and in the laboratory of the Pharmacology Department, School of Medicine, Temple University, Philadelphia – USA.
DETAILED LIST OF BENEFICIARIES
Funding Institution, Coordinator Institution and Scientific Consultant and Technical Support Laboratory
I. FUNDING INSTITUTION (FI)
Sunset Molecular Discovery LLC, a US-based limited liability corporation based in Santa Fe, New Mexico, USA
II. COORDINATOR INSTITUTION (CI)
The Pharmacology Department, Faculty of Medicine, University of Medicine and Pharmacy Craiova, ROMANIA
III. SCIENTIFIC CONSULTANT
AND TECHNICAL SUPPORT LABORATORY (SCTSL)
The Pharmacology Department, School of Medicine, Temple University, Philadelphia – USA
Sunset Molecular Discovery LLC, a US-based limited liability corporation based in Santa Fe, New Mexico, USA, represented by Luis A. Suarez, Ph.D.
Having a long-standing interest in GPER physiology, and recognising that:
- the presence of GPER in myometrium is poorly studied and its function is not understood;
- this receptor could explain some of the rapid uterine responses to massive estrogen administration;
- the variation of the GPER density in pregnancy may contribute to the characteristic variation of myometrial contractility during gestation.
has selected the project:
Study of GPER as a”rapid” receptor for estrogen in myometrial smooth muscle
after analyzing all applications submitted in the time announced, for the following arguments:
- the ability of the Coordinator Institution to perform the work described in the Project;
- the ability of the Scientific Consultant to provide background, supporting work and independent research as described in the Project;
- the proven track record of the Coordinator Institution and the Scientific Consultant to work effectively as a team.