1.1.Setting up project management
1.2.Initiation of histological / immunohistochemical and image analysis.
1.1. Work meeting between partners; establishing the final working protocols. Signing an agreement with the Ethics Committee of UMF Craiova / UMF Carol Davila Bucharest; creating a dedicated web page.
1.2.a. Intracerebral injection of Aβ40 with/without the AQP4 inhibitor. In vivo analysis under two photon microscopy.
1.2.b. Tissue processing and archiving for histological and immunohistochemica; examination.
1.2.c. Tissue investigation (histopathology and immunohistochemistry)
1.2.d. Transmission electron microscopy and data analysis.
1.2.e. Immunohistochemical screening of dural lymphatic vessels.
1.2.f. Data dissemination.
Phase 2 (2018) ( 6 months )
2.1. Continuation of the screening for dural lymphatic vessels.
2.2. Final integrative data analysis.
2.1. Continuation and finalizing of the screening for dural lymphatic vessels
2.2.a. Continuation and finalizing of microscopic image analysis.
2.2.b. Finalizing and integration of morphological and immunohistochemical data
2.2.c. Data dissemination.